The correlation between cyclic vomiting syndrome and small intestinal bacterial overgrowth in children
10.3760/cma.j.issn.1673-4912.2025.01.006
- VernacularTitle:儿童周期性呕吐综合征与小肠细菌过度生长的关系
- Author:
Ningning LI
1
;
Lin SONG
;
Jian WANG
;
Lan HE
;
Yutang REN
;
Lina JI
;
Xiwei XU
Author Information
1. 国家儿童医学中心 首都医科大学附属北京儿童医院100045
- Publication Type:Journal Article
- Keywords:
Cyclic vomiting syndrome;
Children;
Small intestinal bacterial overgrowth;
Clinical feature
- From:
Chinese Pediatric Emergency Medicine
2025;32(1):27-32
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To summarize the clinical symptoms of cyclic vomiting syndrome（CVS）in children and investigate its association with small intestinal bacterial overgrowth（SIBO）.Methods:A total of 89 children who were diagnosed as CVS and improved lactulose hydrogen breath test (LHBT) in the Pediatric Department of Beijing Tsinghua Changgung Hospital from June 2020 to June 2023 were selected as CVS group.Simultaneously，50 healthy children with physical examination in our hospital were selected as the control group. According to the results of LHBT,the children with CVS were divided into SIBO group (LHBT positive) and non-SIBO group (LHBT negative). The clinical data of children in each group were compared.Results:Among the 89 CVS patients，there were 42 males and 47 females，with a mean age of（7.50±3.54）years.Common accompanying symptoms included excessive sleepiness（76 cases，85.39%），anorexia(62 cases，69.66%），constipation（55 cases，61.80%），abdominal pain（34 cases,38.20%）and so on. There were no significant differences in age and gender between children in CVS group and control group ( P>0.05). The body mass index of CVS group was lower than that of control group.The positive rate of LHBT was higher than that of the control group (56.18% vs. 8.00%),the difference was statistically significant ( P<0.05),and the concentrations of hydrogen and methane in CVS group were higher than those of the control group at different time points( P<0.05).Among 89 children with CVS,there were 50 cases in SIBO group and 39 cases in non-SIBO group. There were no significant differences in gender,age and body mass index between the two groups ( P>0.05). The constipation rate and moderate/severe disease rate in SIBO group were higher than those in non-SIBO group (88.00% vs. 28.21%,94.00% vs. 43.59%),and the differences were statistically significant ( P<0.05). Conclusion:The incidence of SIBO in children with CVS is higher,and SIBO may play a key role in CVS. CVS children with SIBO have higher disease severity.
