Research progress on regulatory effect of Sema6D on immune cells
10.3969/j.issn.1000-484X.2025.07.001
- VernacularTitle:Sema6D对免疫细胞调控作用的研究进展
- Author:
Yingjie WANG
1
;
Hui PENG
1
Author Information
1. 中国科学技术大学生命科学与医学部,前沿交叉科学与生物医学研究所,合肥 230027
- Publication Type:Journal Article
- Keywords:
Sema6D;
Immune cells;
Regulatory role
- From:
Chinese Journal of Immunology
2025;41(7):1537-1542
- CountryChina
- Language:Chinese
-
Abstract:
Sema6D,a member of Semaphorin protein family,is a type Ⅰ single-pass transmembrane protein whose expres-sion vary across different tissues.Known ligands for Sema6D include transmembrane proteins PlexinA1 and PlexinA4.Upon binding its ligands,intracellular domain of Sema6D recruits and activates tyrosine kinase Abl,thereby regulating cellular activities such as migration,adhesion and polarization.Early research primarily focused on role of Sema6D in regulating nervous system.Recent studies,however,have revealed that Sema6D is expressed on various immune cells and participates in modulating immune functions.Sema6D can mediate anti-inflammatory polarization of macrophages through metabolic reprogramming,inhibit secretion of pro-inflammatory cyto-kines by dendritic cells while promoting their migration,and enhance proliferation of CD4?T cells.Furthermore,Sema6D itself can act as a ligand,regulating function of PlexinA1? type 2 innate lymphoid cells and PlexinA4?T cells.This review summarizes recent advances in understanding how Sema6D regulates functions of these immune cells,highlighting its multifaceted roles within immune system and providing novel insights into immune homeostasis and disease mechanisms.
