Effect of Dulagopeptide on Physical Examination Indexes,Plasma Glucose Metabolism and Islet Function in Type 2 Diabetes Mellitus Patients with Poorly Controlled Plasma Glucose
10.13241/j.cnki.pmb.2025.17.009
- VernacularTitle:度拉糖肽对血糖控制不佳2型糖尿病患者体格检查指标、血糖代谢及胰岛功能的影响
- Author:
Zhong-yu ZHOU
1
;
Cong WANG
1
;
Lin WANG
1
;
Zhuang-sen CHEN
1
;
Ying HUANG
1
;
Cai-yan HUANG
1
;
Kun FENG
1
Author Information
1. 深圳市坪山区人民医院内分泌科 广东 深圳 518118
- Publication Type:Journal Article
- Keywords:
Dulagopeptide;
Type 2 diabetes mellitus;
Metformin;
Physical indexes;
Plasma glucose metabolism;
Islet function
- From:
Progress in Modern Biomedicine
2025;25(17):2790-2796,2834
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of dulagopeptide on physical examination indexes,plasma glucose metabolism and islet function in type 2 diabetes mellitus(T2DM)patients with poorly controlled plasma glucose.Methods:135 T2DM patients with poorly controlled plasma glucose who were admitted in our hospital from January 2023 to July 2024 were selected.A prospective randomized controlled design was adopted,they were divided into control group 1(received treatment with sitagliptin,n=45),control group 2(received treatment with insulin glargine,n=45),and observation group(received treatment with dulaglutide,n=45)according to the random number table method.Physical examination indexes,plasma glucose indicators,islet function,and incidence of adverse reactions were compared among the three groups.Results:12 weeks after treatment,body mass index(BMI),waist circumference,fasting plasma glucose(FPG),glycated hemoglobin(HbA1c),and postprandial 2-hour plasma glucose(2hPG)in the observation group were lower than those in control group 1 and control group 2(P＜0.05).12 weeks after treatment,the observation group had the highest HbA1c compliance rate,reaching 71.1％(P＜0.05).12 weeks after treatment,the fasting C-peptide(FC-P)and HOMA-islet(CP-DM)levels in the observation group were higher than those in control group 1 and control group 2(P＜0.05).Conclusion:Dulagopeptide can effectively improve physical examination indexes,plasma glucose indicators,and islet function in T2DM patients with poorly controlled plasma glucose.
