Molecular Mechanisms and Research Progress of Hepatic Injury Induced by Hypercholesterolemia
10.13241/j.cnki.pmb.2025.17.019
- VernacularTitle:高胆固醇血症诱导肝损伤的分子机制与研究进展
- Author:
Xing-tong LAN
1
;
Yi-fan WANG
1
;
Meng-yuan LIU
1
;
Zi-yi GUO
1
;
Jin-bo ZHANG
1
;
Qi-hang WANG
1
;
Yu-dian ZHANG
1
Author Information
1. 首都医科大学基础医学院 北京 100069
- Publication Type:Journal Article
- Keywords:
Hypercholesterolemia;
Hepatic injury;
Cholesterol metabolism disorder
- From:
Progress in Modern Biomedicine
2025;25(17):2865-2874
- CountryChina
- Language:Chinese
-
Abstract:
Hypercholesterolemia is pathologically characterized by abnormal accumulation of low-density lipoprotein cholesterol,which is closely associated with metabolic dysfunction-associated fatty liver disease and increased cardiovascular risks.Hepatocytes maintain cholesterol homeostasis through LDL receptor-mediated uptake and esterification storage mechanisms.However,chronic cholesterol overload induces mitochondrial dysfunction,reactive oxygen species accumulation,and endoplasmic reticulum stress,leading to hepatocyte injury.Moreover,systemic hypercholesterolemia disrupts gut microbiota balance and impairs short-chain fatty acid and ketone metabolism,exacerbating metabolic disturbances and aggravating hepatic injury through enhanced metabolic stress.In this article,we review the advance of studies on hypercholesterolemia in recent years and summary its association with hepatic injury,which can provide theoretical support for further research.
