Analysis of Helicobacter pylori infection status and drug resistance in children in Wuxi area
10.3760/cma.j.issn.1673-4912.2024.12.008
- VernacularTitle:无锡地区儿童幽门螺杆菌感染状况及耐药性分析
- Author:
Junfeng HUANG
1
;
Xuyang WANG
;
Qiong LIN
Author Information
1. 江南大学附属无锡市儿童医院消化科214000
- Publication Type:Journal Article
- Keywords:
Helicobacter pylori;
Antibiotics;
Resistance;
Children
- From:
Chinese Pediatric Emergency Medicine
2024;31(12):920-923
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze Helicobacter pylori（Hp）infection and drug resistance in outpatient children in Wuxi，Jiangsu Province，China，and guide the rational use of drugs.Methods:The clinical data of children who were treated in the outpatient clinic of the Gastroenterology Department at Wuxi Children's Hospital for upper gastrointestinal symptoms and underwent gastroscopy from January 2020 to February 2024 were collected.The Hp infection and drug resistance status were analyzed.Results:A total of 2 119 children with upper gastrointestinal symptoms underwent gastroscopy，of which 669 children（31.6%）had positive gastric mucosal Hp isolation and culture，including 363 males and 306 females，and there was no significant difference in Hp positivity rate between different genders（ P>0.05）.There were 41（6.1%）cases aged <8 years，300（44.8%）casesa ged 8~12 years，and 328（49.0%）cases aged 13~18 years，respectively，and the positive rate of Hp in the age group of 13~18 years was higher than those in 8~12 years and <8 years old，respectively，and the difference was statistically significant（ χ2=236.174， P<0.001）.The results of the antimicrobial susceptibility test showed that the resistance rates of 669 strains of Hp to metronidazole,clarithromycin,and levofloxacin were 72.2%(483/669),33.5%(224/669),and 16.3%(109/669),respectively.No strains resistant to furazolidone，amoxicillin，or tetracycline were found.There were 314(46.9%) strains with dual drug resistance,and the drug resistance rates to metronidazole+clarithromycin,metronidazole+levofloxacin,and clarithromycin+levofloxacin were 23.5%(157/669),14.2%(95/669),and 9.3%(62/669),respectively.There were 48(7.2%) triple drug-resistant strains,all of which were resistant to metronidazole+clarithromycin+levofloxacin.There were no significant differences in the resistance rates of Hp to metronidazole，clarithromycin，and levofloxacin across different genders and among age groups（ P>0.05）. Conclusion:Children with Hp infection in Wuxi area are mainly older children.The resistance rates of Hp to metronidazole and clarithromycin are high,so it is not recommended to use them for empirical Hp eradication treatment.It is suggested that individualized eradication treatment should be carried out according to the results of drug sensitivity test.
