Effects of Xuefu Zhuyu Decoction Combined with Cyproheptanidine Hydrochloride Tablets on Intracranial Arterial Hemodynamics,Oxygen Free Radicals and Vasoactive Factors in Patients with Migraine Caused by Blood Stasis Blocking Meridians
10.13241/j.cnki.pmb.2025.17.008
- VernacularTitle:血府逐瘀汤联合盐酸赛庚啶片对瘀血阻络型偏头痛患者颅内动脉血流动力学、氧自由基和血管活性因子的影响
- Author:
Xiao-li DONG
1
;
Wei SUN
;
Chun DING
Author Information
1. 枣庄市市立医院医疗集团运河医院内科 山东枣庄 277400
- Publication Type:Journal Article
- Keywords:
Xuefu Zhuyu Decoction;
Cyproheptanidine Hydrochloride Tablets;
Blood stasis blocking meridians;
Migraine;
Hemodynamics;
Oxygen free radicals;
Vasoactive factors
- From:
Progress in Modern Biomedicine
2025;25(17):2783-2789
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the effects of Xuefu Zhuyu Decoction combine with Cyproheptanidine Hydrochloride Tablets on intracranial arterial hemodynamics,oxygen free radicals and vasoactive factors in patients with migraine caused by blood stasis blocking meridians.Methods:This study was a single-center prospective randomized controlled study,90 patients with migraine caused by blood stasis blocking meridians who were admitted to Zaozhuang Municipal Hospital Medical Group Canal Hospital from October 2022 to July 2024 were divided into control group(treated with Cyproheptanidine Hydrochloride Tablets,n=45)and study group(treated with Xuefu Zhuyu Decoction combined with Cyproheptanidine Hydrochloride Tablets,n=45)according to the random number table method.The TCM syndrome scores,visual analog scale(VAS),intracranial arterial hemodynamics[anterior cerebral artery(ACA),vertebral artery(VA),middle cerebral artery(MCA),basilar artery(BA)],serum oxygen free radicals[superoxide dismutase(SOD),malondialdehyde(MDA)],serum vasoactive factors[endothelin-1(ET-1),nitric oxide(NO)]between the two groups were compared.Results:The TCM syndrome scores,VAS score,MDA and ET-1 levels in the study group after treatment were lower than those in the control group,while ACA,MCA,VA and BA hemodynamics,and SOD and NO levels were higher than those in the control group(P＜0.05).Conclusion:Xuefu Zhuyu Decoction combined with Cyproheptanidine Hydrochloride Tablets in the treatment of patients with migraine caused by blood stasis blocking meridians,can effectively improve intracranial arterial hemodynamics,control serum oxygen free radicals and vasoactive factors,and prevent the progression of the disease.
