Predictive Value of Serum NGAL,CGRP,and NLR for the Prognostic Regression of Elderly Patients with Stroke Complicated with Pulmonary Infectio
10.13241/j.cnki.pmb.2025.17.014
- VernacularTitle:血清NGAL、CGRP、NLR对老年脑卒中并发肺部感染患者预后转归的预测价值
- Author:
Xiao-jie LI
1
;
Hong-zhe BEI
;
Jin WANG
;
Li-he YUAN
;
Li-rong LIN
;
Xin-hui LI
Author Information
1. 内蒙古包钢医院神经内科 内蒙古包头 014010
- Publication Type:Journal Article
- Keywords:
Elderly;
Stroke;
Pulmonary infection;
Neutrophil gelatinase-associated lipocalin;
Calcitonin gene-related peptide;
Neutrophil-to-lymphocyte ratio;
Prognosis;
Predictive value
- From:
Progress in Modern Biomedicine
2025;25(17):2827-2834
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the predictive value of serum neutrophil gelatinase-associated lipocalin(NGAL),calcitonin gene-related peptide(CGRP),and neutrophil-to-lymphocyte ratio(NLR)for the prognostic regression of elderly patients with stroke complicated with pulmonary infection(SCPI).Methods:This study was a retrospective single-center study,149 elderly patients with SCPI who were admitted to Inner Mongolia Baogang Hospital from June 2020 to June 2024 were selected,they were divided into poor prognosis group(n=56)and good prognosis group(n=93)according to the prognosis.Baseline data and laboratory test indicators were collected,and NLR was calculated.Serum NGAL and CGRP levels were measured by ELISA.Influencing factors of poor prognosis of elderly patients with SCPI were analyzed by Multivariate logistic regression.Predicts value was analyzed by Receiver operating characteristic(ROC)curve.Results:Compared with good prognosis group,the poor prognosis group had higher of aged ≥ 70 years,incidence of hemorrhagic stroke,serum creatinine,white blood cell count,national institute of health stroke scale(NIHSS),platelet count,C-reactive protein,NGAL,and NLR levels,longer nerosurgery intensive care unit(NICU)stay,and lower CGRP levels(P＜0.05).Higher CGRP level was an independent protective factor of poor prognosis of elderly patients with SCPI(OR＜1,P＜0.05).Age ≥ 70 years,hemorrhagic stroke,longer NICU stay,higher NIHSS score,higher NGAL level and higher NLR were independent risk factors of poor prognosis of elderly patients with SCPI(OR＞1,P＜0.05).The area under the curve(AUC)for predicting the prognostic regression of elderly patients with SCPI used NGAL,CGRP,and NLR alone or in combination was 0.777,0.771,0.786,and 0.927,respectively,with the combination of three factors showed the highest predictive power(P＜0.05).Conclusion:Age ≥70 years,hemorrhagic stroke,longer NICU stay,higher NIHSS score,higher NGAL level and higher NLR are independent risk factors of poor prognosis of elderly patients with SCPI,while higher CGRP level is an independent protective factor.The combination detection of NGAL,CGRP and NLR can improve the predictive value of prognostic regression in elderly patients with SCPI.
