Risk factors for sudden cardiac death in children with hypertrophic cardiomyopathy
10.3760/cma.j.issn.1673-4912.2024.12.004
- VernacularTitle:儿童肥厚型心肌病心源性猝死的危险因素
- Author:
Zhen ZHEN
1
;
Xi CHEN
1
;
Jia NA
1
;
Yeqiong XU
1
;
Lu GAO
1
;
Yue YUAN
1
Author Information
1. 国家儿童医学中心 首都医科大学附属北京儿童医院心脏内科100045
- Publication Type:Journal Article
- Keywords:
Hypertrophic cardiomyopathy;
Children;
Sudden cardiac death;
Prognosis
- From:
Chinese Pediatric Emergency Medicine
2024;31(12):900-904
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the risk factors affecting the occurrence of sudden cardiac death（SCD）of hypertrophic cardiomyopathy（HCM）in children.Methods:This was a retrospective study.A total of 184 children with HCM who admitted to Beijing Children's Hospital，Capital Medical University from 1 January，2006 to 31 August，2022 were collected for clinical data and follow-up information.Risk factors affecting the occurrence of SCD in children with HCM were analyzed by Cox regression.Results:A total of 184 children with HCM were included in this study，including 69（37.50%）female cases and 115（62.50%）male cases.Cox regression showed that age less than one year（ HR=6.232，95% CI 2.858-13.591），female gender（ HR=2.547，95% CI 1.460-4.444），family history（ HR=2.622，95% CI 1.468-4.683），pathological Q waves in the electrocardiogram（ HR=2.290，95% CI 1.285-4.082），QRS fragmentation waves（ HR=3.526，95% CI 1.786-6.963），combined multiple arrhythmias（ HR=2.218，95% CI 1.136-4.333），high interventricular septal thickness on echocardiography（ HR=1.055，95% CI 1.008-1.105）,and high left ventricular posterior wall thickness（ HR=1.060，95% CI 1.026 -1.096）were risk factors for endpoint events in children. Conclusion:Age，sex，family history，electrocardiogram changes（pathological Q wave，QRS fragmentation wave，combined multiple arrhythmia），interventricular septum thickness and left ventricular posterior wall thickness are independent risk factors affecting the occurrence of SCD of HCM in children.
