Use of vasopressin in septic shock: timing and monitoring
10.3760/cma.j.issn.1673-4912.2025.05.004
- VernacularTitle:脓毒性休克血管加压素的使用：时机与监测
- Author:
Jie FU
1
;
Yucai ZHANG
;
Yiping ZHOU
Author Information
1. 安徽省亳州市人民医院 亳州市儿童医院重症医学科 236800
- Publication Type:Journal Article
- Keywords:
Vasopressin;
Vasopressor agents;
Septic shock;
Children
- From:
Chinese Pediatric Emergency Medicine
2025;32(5):337-340
- CountryChina
- Language:Chinese
-
Abstract:
Vasopressin is a non-catecholamine agent that induces vasoconstriction via V1 receptors. It is currently regarded as a second-line vasopressor in the treatment of septic shock. According to the Surviving Sepsis Campaign Guidelines for the Management of Sepsis and Septic Shock in Adults,vasopressin is recommended when norepinephrine doses reach 0.25–0.50 μg/（kg·min）and normal blood pressure cannot be maintained. However,hemodynamic alterations in pediatric septic shock differ significantly from those observed in adults,and there is currently insufficient evidence to support the use of vasopressin in pediatric septic shock. This review,in conjunction with recent clinical research data,explored the optimal timing of initiation,methods of administration,and clinical evaluation criteria for vasopressin in septic shock,aiming to provide valuable references for the optimization of septic shock management.
