Effect of Esketamine on the Analgesic Efficacy,Arterial Blood Gas Indicators and Inflammatory Factors of Patients with Severe Mechanical Ventilation
10.13241/j.cnki.pmb.2025.17.017
- VernacularTitle:艾司氯胺酮对重症机械通气患者镇痛效果、动脉血气指标及炎性因子的影响
- Author:
Chun-ping ZOU
1
;
Wen-shui LOU
1
;
Gan WANG
1
Author Information
1. 上饶市人民医院重症医学科 江西上饶 334000
- Publication Type:Journal Article
- Keywords:
Esketamine;
Severe;
Mechanical ventilation;
Analgesia;
Arterial blood gas indicators;
Inflammatory factors
- From:
Progress in Modern Biomedicine
2025;25(17):2851-2856,2864
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of esketamine on the analgesic efficacy,arterial blood gas indicators and inflammatory factors of patients with severe mechanical ventilation.Methods:A prospective study was conducted on 66 patients with severe mechanical ventilation who were admitted to our hospital from December 2022 to June 2024,and they were divided into control group and study group according to the envelope lottery method,with 33 cases in each group.The control group received remifentanil analgesic treatment,and the study group received esketamine analgesic treatment on the basis of the control group.Critical-care pain observation tool(CPOT)score,blood gas indicators[Partial pressure of arterial oxygen(PaO2)and partial pressure of carbon dioxide(PaCO2)],offline success rate,mechanical ventilation time,maximum remifentanil dosage to achieve analgesic goals,inflammatory factors levels[Interleukin(IL)-6,interleukin(IL)-10,white blood cell count(WBC),procalcitonin(PCT)]and the incidence of adverse reactions were compared between the two groups.Results:PaCO2 and CPOT scores decreased,while PaO2 increased after treatment of both groups(P＜0.05).The CPOT scores of the study group was lower than that of the control group after treatment(P＜0.05).The offline success rate of the study group was higher than that of the control group,the mechanical ventilation time was shorter than that of the control group,and the maximum remifentanil dosage to achieve analgesic goals was lower than that of the control group (P＜0.05).IL-6,WBC and PCT levels of the study group after treatment were lower than those of the control group,while IL-10 was higher than that of the control group(P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion:Esketamine in the treatment of patients with severe mechanical ventilation,can effective analgesia,increase offline success rate,shorten mechanical ventilation time,reduce inflammatory factors levels.
