Roles of ncRNAs regulating metabolic reprogramming of TAMs in oncotherapy
10.3969/j.issn.1000-484X.2025.07.012
- VernacularTitle:ncRNAs调控TAMs代谢重编程在肿瘤治疗中的研究进展
- Author:
Zanhan WANG
1
;
Zhihong SUN
;
Hongyan QIN
;
Yiyang HU
Author Information
1. 延安大学生命科学学院,延安 716000;中国人民解放军空军军医大学基础医学院医学遗传与发育生物学教研室,西安 710032
- Publication Type:Journal Article
- Keywords:
Non-coding RNA;
Tumor-associated macrophages;
Metabolic reprogramming
- From:
Chinese Journal of Immunology
2025;41(7):1616-1623
- CountryChina
- Language:Chinese
-
Abstract:
Vast majority of human RNA are non-coding RNA(ncRNA),which can regulate physiological activities and affects functions on cells.Although each part of them is obscure,they are involved in different levels of gene regulation,from epigene-tic gene silencing to post transcriptional regulation.Metabolic reprogramming of tumor-associated macrophages(TAMs)can promote tumor progression and is closely related to activation phenotypes of anti-tumor(M1)or pro-tumor(M2).A lot of ncRNAs are involved in metabolic reprogramming of TAMs,reshaping tumor microenvironment and playing a key role in tumor progression.Improving understanding of effect on ncRNA regulating metabolic reprogramming of TAMs may provide new methods for developing effective clinical treatments.
