Clinical Study of Modified Cangfu Daotan Decoction Combined with Ethinylestradiol and Cyproterone Acetate,Metformin in Patients with Spleen Deficiency Phlegm-Dampness Type Polycystic Ovary Syndrome Accompanied by Insulin Resistance
10.13241/j.cnki.pmb.2025.17.006
- VernacularTitle:苍附导痰汤加减联合炔雌醇环丙孕酮、二甲双胍对脾虚痰湿型多囊卵巢综合征伴胰岛素抵抗患者的临床研究
- Author:
Jing LIN
1
;
Fan CHEN
1
;
Yan-hua CHEN
1
;
Ying XU
1
;
Lin-lin WANG
1
;
Hong WANG
1
;
Xi-na LIAN
1
;
Rong-qian XU
1
Author Information
1. 福建中医药大学附属第三人民医院妇科 福建 福州 350108
- Publication Type:Journal Article
- Keywords:
Metformin;
Modified Cangfu Daotan Decoction;
Polycystic ovary syndrome;
Ethinylestradiol and cyproterone acetate;
Spleen deficiency phlegm-dampness type;
Insulin resistance
- From:
Progress in Modern Biomedicine
2025;25(17):2768-2775,2739
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the clinical effect of Cangfu Daotan Decoction combined with ethinylestradiol and cyproterone acetate,metformin in patients with spleen deficiency phlegm-dampness type polycystic ovary syndrome(PCOS)accompanied by insulin resistance.Methods:80 patients with PCOS accompanied by insulin resistance who were admitted to our hospital from June 2023 to June 2024 were included.The patients were divided into control group(treated with ethinylestradiol and cyproterone acetate,metformin)and study group(treated with modified Cangfu Daotan Decoction combine with ethinylestradiol and cyproterone acetate,metformin)by the random number table method,with 40 cases in each group.The total clinical effective rate,TCM syndrome score,sex hormone levels[prolactin(PRL),estradiol(E2),follicle-stimulating hormone(FSH),testosterone(T),and luteinizing hormone(LH)],insulin resistance indicators[fasting insulin(FINS),fasting blood glucose(FBG),homeostatic model assessment of insulin resistance(HOMA-IR)],and endometrial receptivity[pulsatile index(PI),resistance index(RI),endometrial thickness(ET),ovulation rate]and the occurrence of adverse reactions were compared between the two groups.Results:Compared with the control group after treatment,the total clinical effective rate,PRL,E2,FSH level,ET and the ovulation ratein the study group were higher,while the main symptoms,secondary symptoms,total score,T,LH levels,FBG,FINS levels,HOMA-IR,PI and RI were lower(P＜0.05).There was no difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion:Cangfu Daotan Decoction combined with ethinylestradiol and cyproterone acetate,metformin in patients with spleen deficiency phlegm-dampness type PCOS accompanied by insulin resistance,can improve the clinical symptoms,increase the total clinical effective rate,it may be related to the regulation of insulin resistance,sex hormone levels,and endometrial receptivity,it is safe and reliable.
