A case report of acute kidney injury associated with pegylated recombinant human granulocyte colony-stimulating factor injection
10.12173/j.issn.1005-0698.202503088
- VernacularTitle:聚乙二醇化重组人粒细胞刺激因子注射液致急性肾损伤1例
- Author:
Hong ZHONG
1
;
Hongbo QIU
;
Xuanyi ZHANG
;
Wenqiang KONG
Author Information
1. 自贡市第一人民医院药剂科(四川自贡 643000)
- Publication Type:Journal Article
- Keywords:
Pegylated recombinant human granulocyte colony-stimulating factor;
Acute kidney injury;
Adverse drug reaction
- From:
Chinese Journal of Pharmacoepidemiology
2025;34(9):1104-1107
- CountryChina
- Language:Chinese
-
Abstract:
A 58-year-old female patient with breast cancer received treatment with pegylated recombinant human granulocyte colony-stimulating factor(PEG-rhG-CSF)injection after adjuvant chemotherapy.The serum creatinine level of the patient gradually increased from the normal baseline value to 199.3 μmol·L-1.The patient was diagnosed as acute kidney injury(AKI),after stopping the medication and providing symptomatic treatment,the patient's renal function gradually improved.The patient completed subsequent chemotherapy as planned without reusing PEG-rhG-CSF injection,and other medications and dosages remained unchanged.Renal function remained stable during follow-up.Naranjo's Assessment Scale was used to evaluate the association between PEG-rhG-CSF injection and AKI,the result was"probable."There are few reports of AKI occuring with PEG-rhG-CSF injection,and this case provides evidence for clinical safe medication.
