Observation on the efficacy of Huoluo Xiaotong capsules in treating cervical spondylosis radiculopathy:a real-world study
10.12173/j.issn.1005-0698.202505054
- VernacularTitle:基于真实世界研究的活络消痛胶囊治疗神经根型颈椎病疗效观察
- Author:
Xiangzhou LAN
1
;
Weike ZENG
;
Shasha ZHOU
;
Gaoyan KUANG
;
Cheng GUO
;
Qing CHEN
Author Information
1. 湖南中医药大学第一附属医院骨伤科(长沙 410007)
- Publication Type:Journal Article
- Keywords:
Cervical spondylosis radiculopathy;
Huoluo Xiaotong capsules;
Real-world study;
Efficacy evaluation
- From:
Chinese Journal of Pharmacoepidemiology
2025;34(9):1025-1031
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the early efficacy and safety of Huoluo Xiaotong capsules and Jingtong granules in treating cervical spondylosis radiculopathy(CSR).Methods A real-world study was conducted among CSR patients who visited three tertiary-grade-A hospitals in Changsha between January 2024 and February 2025.Patients were divided into a control group(Jingtong granules,4 g,po,tid)and an observation group(Huoluo Xiaotong capsules,1.4 g,po,tid);both groups were treated for 2 weeks.Baseline characteristics were balanced with inverse probability of treatment weighting(IPTW).Numeric rating scale(NRS)scores,overall response rates,and traditional Chinese medicine(TCM)symptom scores were compared at baseline,1 week,and 2 week.Results A total of 120 patients were ultimately included,with 30 in the control group and 90 in the observation group.After IPTW adjustment,at 1 week of treatment,the clinical efficacy rate of observation group(98.85％)were significantly exceeded that of control group(80.14％)(P＜0.001);at 2 weeks,the clinical efficacy rate of the two groups were both 100.00％.NRS and TCM syndrome scores showed no intergroup differences at baseline or 1 week(P＞0.05),at 2 weeks,the observation group demonstrated significantly lower NRS and TCM syndrome scores versus controls(P＜0.001).No adverse reactions occurred in either group.Conclusion Huoluo Xiaotong capsules demonstrate favorable short-term efficacy and safety in CSR,significantly alleviating pain and improving TCM symptoms within 2 weeks.High-quality randomized controlled trials are warranted to confirm these findings.
