Comparison of clinical efficacy and safety of cold snare polypectomy and the combination of endoscopic mucosal resection and argon-plasma coagulation in treating colon polyps
- VernacularTitle:冷圈套息肉切除术与内镜黏膜切除术联合氩等离子体凝固术治疗结肠息肉的临床疗效及安全性比较
- Author:
Kai WANG
1
;
Song XUE
1
Author Information
- Publication Type:Journal Article
- Keywords: colon polyps; endoscopic mucosal resection(EMR); cold snare polypectomy(CSP); argon-plasma coagulation(APC); clinical efficacy; safety
- From: China Journal of Endoscopy 2025;31(9):55-61
- CountryChina
- Language:Chinese
- Abstract: Objective To investigate the clinical efficacy and safety of cold snare polypectomy(CSP)and the combination of endoscopic mucosal resection(EMR)and argon-plasma coagulation(APC)in treating colon polyps.Methods From March 2022 to June 2023,80 patients with colon polyps were randomly grouped into the combined surgery group(treated with EMR+APC,40 cases)and the CSP group(treated with CSP,40 cases).Two groups were compared in terms of perioperative indicators,clinical efficacy,pain level,inflammatory cytokine levels,and safety.Results The polyp resection time and total operation time in the CSP group were significantly shorter than those in the combined operation group,and the differences were statistically significant(P＜0.05).The visual analogue scale(VAS)score of the CSP group 24 h after surgery was significantly lower than that of the combined surgery group,and the difference was statistically significant(P＜0.05).The levels of interleukin-6(IL-6)and interleukin-8(IL-8)in both groups of patients 1 day after the operation were significantly higher than those before the operation,and the levels in the combined operation group were significantly higher than those in the CSP group,the differences were statistically significant(P＜0.05).There were no statistically significant differences in intraoperative blood loss,hospital stay,clinical efficacy,and VAS score at 72 h after surgery between the two groups(P＞0.05).The incidence of adverse reactions was 15.00％in the combined surgery group and 5.00％in the CSP group,with no statistically significant difference(P＞0.05).Conclusion Both combination of EMR and APC scheme and CSP scheme can effectively improve the symptoms of colon polyps patients,enhance clinical efficacy,and have lower incidence of adverse reactions,with good treatment safety.However,CSP can accelerate polyp resection speed,shorten surgical time,and alleviate early postoperative pain and inflammatory cytokine levels in patients compared to combination of EMR and APC.
