Research progress on animal models of cancer-induced bone pain and mechanisms of traditional Chinese medicines

VernacularTitle:骨癌痛动物模型及中医药相关镇痛机制研究进展
Author: Jun ZHANG ¹ ; Liya TIAN ; Qin HUANG ; Fangfei LI ; Jie CAO ; Wei WANG
Author Information

1. 重庆大学附属肿瘤医院,重庆 400030
Publication Type:Journal Article
Keywords: cancer-induced bone pain; animal models; traditional Chinese medicine; mechanisms
From: Acta Laboratorium Animalis Scientia Sinica 2025;33(6):925-934
CountryChina
Language:Chinese
Abstract: Cancer-induced bone pain(CIBP)causes substantial suffering for cancer patients and also diminishes their quality of life and self-esteem.The mechanisms underlying CIBP are complex and evolve progressively with cancer advancement.Current treatment options show limited efficacy and are often accompanied by adverse effects.Traditional Chinese medicine demonstrates potential advantages in managing CIBP;however,the mechanisms of action remain poorly understood and require further investigation.The development of a standardized,stable,and reproducible animal model is crucial to advancing research on disease pathogenesis and verifying the effectiveness of therapeutic interventions.This review considers recent method for modeling CIBP in animals and summarizes the application of these models in studies of traditional Chinese medicine mechanisms,with the aim of guiding future research directions in CIBP.