Effect of PTPRZ1 on ANE-induced oral mucosal fibroblasts in mice

VernacularTitle:PTPRZ1对ANE诱导下小鼠口腔黏膜成纤维细胞影响的实验研究
Author: Hongchi ZHANG ¹ ; Yan ZHAI ; Sen MU
Author Information

1. 518034,广州中医药大学深圳医院(福田)
Publication Type:Journal Article
Keywords: PTPRZ1; ANE; Oral mucosa fibroblast cells; Stamina; Apoptosis; PI3K/AKT signaling pathway
From: Journal of Practical Stomatology 2025;41(5):707-710
CountryChina
Language:Chinese
Abstract: Previous studies have shown that PTPRZ1 has a regulatory effect on PI3K/AKT signaling pathway and has the potential to be-come a new protein regulating fibroblasts.Oral mucosal fibroblasts were randomly divided into control group,ANE group,ANE+ov-PT-PRZ1 group and ANE+ov-NC group.Cell viability and apoptosis,expression of PTPRZ1,PI3K and AKT were detected.Mice with oral submucosal fibrosis were established and the expressions of PI3K and AKT were detected.The overexpression of PTPRZ1 can regulate the apoptosis and activity of oral mucosal fibroblasts induced by ANE in a dose-dependent manner,and PTPRZ1 can regulate oral mucosal fi-broblasts by activating the PI3K/AKT signaling pathway of oral mucosal fibroblasts,promoting fibrosis and aggravating the disease.