Mouse models of hereditary dentine disorders and relevant research methods
10.3969/j.issn.1001-3733.2025.05.019
- VernacularTitle:遗传性牙本质发育异常小鼠模型及相关研究方法
- Author:
Xiaomei FENG
1
;
Xiaohong DUAN
1
Author Information
1. 710032 西安,口颌系统重建与再生全国重点实验室,国家口腔疾病临床医学研究中心,陕西省口腔医学重点实验室,空军军医大学口腔医院口腔生物学教研室
- Publication Type:Journal Article
- Keywords:
Mouse model;
Odontogenesis;
Dentinogenesis;
Dentinogenesis imperfecta;
Dentin dysplasia
- From:
Journal of Practical Stomatology
2025;41(5):692-700
- CountryChina
- Language:Chinese
-
Abstract:
Hereditary dentine disorders are a series of diseases with abnormal dentin structure and mineralization caused by ge-netic factors,of which the proceeding and genetic mechanisms could be effectively studied based on mouse models.This review in-troduces the basic classification and common pathogenic genes of hereditary dentine disorders,and overviews developmental char-acteristics as well as major markers of mouse dentin.Various types of genetically modified mice simulating human hereditary den-tine disorders are briefly described,providing a theoretical foundation for the deep study of these kinds of diseases.
