Research advances in the pathogenesis of intracranial arterial dolichoectasia induced by matrix metalloproteinases
10.3969/j.issn.1671-7856.2025.06.017
- VernacularTitle:基质金属蛋白酶与颅内动脉延长扩张症的病理机制研究进展
- Author:
Xiaofang GUAN
1
;
Daopei ZHANG
Author Information
1. 河南中医药大学第一临床医学院,郑州 450000
- Publication Type:Journal Article
- Keywords:
intracranial arterial dolichoectasia;
matrix metalloproteinases;
vertebrobasilar dolichoectasia;
positive reconstruction;
Willis mutation;
intracranial aneurysm
- From:
Chinese Journal of Comparative Medicine
2025;35(6):159-166
- CountryChina
- Language:Chinese
-
Abstract:
Intracranial arterial dolichoectasia(IADE)is a major arterial disease characterized by artery elongation,dilatation,and curvature.Although the pathological mechanism of IADE is unclear,recent studies have suggested a close relationship with matrix metalloproteinases(MMPs).This review summarizes the possible pathological mechanism of IADE induced by MMPs in terms of MMPs activation and the occurrence and development of IADE,the correlation between MMPs activation and positive remodeling causing IADE,and the relationship between hemodynamic changes,MMPs activation and IADE and between IADE-associated diseases and MMPs,to provide potential therapeutic targets for the effective prevention and treatment of IADE.
