Role of nitric oxide synthase in the pathogenesis of Alzheimer's disease
10.3969/j.issn.1671-7856.2025.06.016
- VernacularTitle:一氧化氮合酶在阿尔茨海默病发病机制中的作用
- Author:
Keying JIANG
1
;
Ying LIU
;
Jiaying LIU
;
Jingyi LI
;
Zhikui WU
;
Meiwen YANG
;
Fenfang HONG
;
Shulong YANG
Author Information
1. 南昌大学抚州医学院生理学教研室,江西抚州 344100;南昌大学抚州医学院慢性病研究重点实验室,江西抚州 344100;抚州市慢性病研究技术创新中心,江西抚州 344100
- Publication Type:Journal Article
- Keywords:
Alzheimer's disease;
nitric oxide synthase;
pathogenesis;
nitric oxide
- From:
Chinese Journal of Comparative Medicine
2025;35(6):151-158
- CountryChina
- Language:Chinese
-
Abstract:
Nitric oxide synthase(NOS)and its product nitric oxide are involved in learning and memory functions.Increasing evidence shows that NOS plays an important role in the pathogenesis of Alzheimer's disease,influencing β-amyloid protein(Aβ)deposition,neuroinflammation,oxidative stress,abnormal microglia activation,synapse damage,autophagy,abnormal mitochondrial function of nerve cells,and cerebral hypoperfusion or vascular endothelial cell injury.This review summarizes the recent evidence for the role of NOS in the pathogenesis of Alzheimer's disease and provides new feasible targets for the prevention and treatment of Alzheimer's disease.
