Research progress on moxibustion therapy for regulating inflammatory responses for the treatment of bone-related diseases
10.3969/j.issn.1671-7856.2025.06.012
- VernacularTitle:艾灸疗法调控炎性反应治疗骨相关疾病的研究进展
- Author:
Xing LI
1
;
Xiao LI
;
Xiaoli CHEN
;
Lu CUI
;
Xiaojuan HONG
;
Xiaoshen HU
;
Xiang LI
Author Information
1. 成都中医药大学针灸推拿学院,成都 611137
- Publication Type:Journal Article
- Keywords:
moxibustion;
bone-related diseases;
inflammatory response;
research progress
- From:
Chinese Journal of Comparative Medicine
2025;35(6):104-118
- CountryChina
- Language:Chinese
-
Abstract:
The advent of an aging society means that bone-related diseases impose a substantial burden on the general population and on healthcare systems,highlighting the need to find new treatment method.The occurrence and progression of such diseases are closely linked to inflammatory responses.Moxibustion,as a traditional external treatment in traditional Chinese medicine(TCM),is well-known for its anti-inflammatory and analgesic effects,and it has also demonstrated remarkable therapeutic efficacy for bone-related diseases.Here we review the impact of moxibustion on inflammatory responses associated with bone-related conditions.The anti-inflammatory mechanism of moxibustion in treating bone-related diseases involves mediating pro-inflammatory and anti-inflammatory factors and related mediators,and regulating signaling pathways(e.g.,nuclear factor-kappa B(NF-κB),Janus kinase(JAK)/signal transducer and activator of transcription(STAT),mitogen-activated protein kinase(MAPK),programmed death receptor-1(PD-1)/programmed death ligand-1(PD-L1),adenosine monophosphate-activated protein kinase(AMPK)/UNC-51 like autophagy activating kinase(ULK1)),the hypothalamic-pituitary-adrenal axis,the activation of immune cells,and autophagy.Despite these findings however,the anti-inflammatory mechanisms underlying moxibustion treatment for bone-related diseases remain poorly understood.Further research utilizing advanced technologies is needed to gain a more comprehensive understanding of the anti-inflammatory mechanisms involved in moxibustion therapy.This approach aims to facilitate better clinical applications and contribute to safeguarding human bone health.
