Application of spatial metabolomics in oral squamous cell carcinoma research
10.3969/j.issn.1001-3733.2025.05.020
- VernacularTitle:空间代谢组学在口腔鳞癌研究中的应用进展
- Author:
Huiting ZHAO
1
;
Qingang HU
;
Xihu YANG
Author Information
1. 212001 镇江,江苏大学附属医院口腔科
- Publication Type:Journal Article
- Keywords:
Spatial metabolomics;
Oral squamous cell carcinoma;
Early diagnosis;
Prognosis evaluation
- From:
Journal of Practical Stomatology
2025;41(5):701-706
- CountryChina
- Language:Chinese
-
Abstract:
Oral and maxillofacial tumors significantly impact human health,with oral squamous cell carcinoma(OSCC)being par-ticularly prevalent among head and neck tumors.At present,traditional research in this area has largely relied on genomics,pro-teomics,and transcriptomics,which involve the homogenization of tissue specimens and result in the loss of critical temporal and spatial tissue information.In contrast,spatial metabolomics,an emerging field,allows for the in-situ analysis of fresh tissue sam-ples,preserving this essential information.This article reviews the application of spatial metabolomics in OSCC research,highlight-ing its potential to enhance understanding of cancer pathogenesis directly within the tissue context.
