Preparation and evaluation of animal models of chronic ulcers on the body surface
10.3969/j.issn.1005-4847.2025.06.010
- VernacularTitle:体表慢性难愈创面动物模型制备及研究进展
- Author:
Zhengqing SUN
1
;
Shaoshuang YUAN
;
Tong ZHAO
;
Yu ZHANG
;
Zhaohui ZHANG
;
Qiang XU
Author Information
1. 天津中医药大学,天津 301617
- Publication Type:Journal Article
- Keywords:
chronic wound;
chronic ulcer;
refractory wound;
animal model
- From:
Acta Laboratorium Animalis Scientia Sinica
2025;33(6):878-892
- CountryChina
- Language:Chinese
-
Abstract:
Chronic ulcers on the body surface are non-healing wounds.Establishing a suitable animal model of chronic wounds will provide an important tool for research aimed at preventing and understanding the complexity of chronic wound formation and related pathological mechanisms in the human body.Animal wound models are usually constructed by inducing molecular abnormalities via external injury interventions to induce wound formation.Common modeling method include surgical resection,pressure ischemia,drugs,and radiation treatment.The success of model construction can then be evaluated by various monitoring method,such as natural recovery of the wound without intervention,measurement of wound size observation of physical signs,measurement of body mass,organ index,and infrared imaging.Despite the existence of numerous modeling and evaluating method,however,there is currently a lack of unified standards for animal chronic wound models.Researchers should thus choose appropriate modeling and model-evaluation method based on their actual needs,to obtain the best experimental result.
