Progress in mechanism of 3-hydroxy-3-methylglutaryl coenzyme A re-ductase
- VernacularTitle:3-羟基-3-甲基戊二酰辅酶A还原酶调控机制的研究进展
- Author:
Xingtong CHEN
1
;
Jinbiao YANG
1
;
Yunyue ZHOU
1
;
Shuaihu YANG
1
;
Ruihong YANG
1
;
Shijian FANG
1
;
Yuxue MA
1
;
Wenying NIU
1
Author Information
- Publication Type:Journal Article
- Keywords: 3-hydroxy-3-methylglutaryl coenzyme A reductase; hypercholesterolemia; cholesterol
- From: Chinese Journal of Pathophysiology 2025;41(4):791-797
- CountryChina
- Language:Chinese
- Abstract: Cholesterol is a crucial lipid in the human body.Elevated levels of cholesterol can result in condi-tions such as hypercholesterolemia.3-hydroxy-3-methylglutaryl coenzyme A reductase(HMGCR)serves as a pivotal en-zyme in the synthesis of cholesterol,acting as a rate-limiting factor.As a result,HMGCR plays a critical role in maintain-ing cholesterol balance,with the regulatory processes being intricate in vivo.This review outlines the advancements in un-derstanding the regulatory mechanisms of HMGCR,encompassing transcriptional control,degradation pathways,and en-zyme activity.
