Progress in pathogenesis and treatment of diabetic neuropathy regulated by microglia polarization
10.3969/j.issn.1000-4718.2025.04.017
- VernacularTitle:小胶质细胞极化调控糖尿病神经病变的发病机制及治疗研究进展
- Author:
Li ZHANG
1
;
Hongmin YANG
;
Jiao HU
;
Sirui YAO
;
Haoran XU
;
Wendi LUO
;
Tao XU
;
Bo HUANG
Author Information
1. 遵义医科大学第三附属医院儿童重症医学科,贵州 遵义 563000
- Publication Type:Journal Article
- Keywords:
diabetic neuropathy;
microglia;
polarization;
pathogenesis
- From:
Chinese Journal of Pathophysiology
2025;41(4):766-774
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic neuropathy(DN)is a prevalent chronic complication of diabetes,characterized by a com-plex pathogenesis involving various cell types and molecular pathways.Research indicates that microglia,serving as the innate immune cells of the central nervous system,are pivotal in the development of DN.In recent years,with the in-depth understanding of the pathogenesis of DN,targeting microglia polarization has become a new research hotspot.This article provides an overview of current research on the regulatory mechanisms of microglia polarization,the impact of mi-croglia polarization on DN,and treatment strategies that target microglia polarization to improve DN.The objective is to elucidate the pivotal role of microglia in the pathogenesis of DN,and assess the efficacy and constraints of existing and emerging treatment methods targeting microglia,in order to offer a fresh perspective for future research and clinical treat-ment of DN.
