Progress in mechanism of hypoxia-induced pulmonary vascular endothe-lial-mesenchymal transition in pulmonary arterial hypertension
10.3969/j.issn.1000-4718.2025.04.022
- VernacularTitle:低氧诱导肺动脉高压肺血管内皮-间充质转化作用机制的研究进展
- Author:
Yuxiang WANG
1
;
Lan MA
1
Author Information
1. 青海大学高原医学研究中心,青海 西宁 810008
- Publication Type:Journal Article
- Keywords:
hypoxia;
pulmonary hypertension;
endothelial-mesenchymal transition
- From:
Chinese Journal of Pathophysiology
2025;41(4):804-808
- CountryChina
- Language:Chinese
-
Abstract:
Hypoxia leads to persistent constriction and remodeling of pulmonary blood vessels,resulting in pulmonary hypertension(PH)and,in severe cases,right heart failure.Endothelial-mesenchymal transition(EndMT)is a biological process in which endothelial cells undergo functional and phenotypic transformation into mesenchymal cells,playing a critical role in pulmonary vascular remodeling.Recent studies have revealed that hypoxia promotes pulmonary vascular EndMT in PH through the mechanisms involving inflammation,transcription factors,signaling pathways,circular RNAs,and microRNAs.This article provides a review of recent research on the mechanisms of hypoxia-induced pulmo-nary vascular EndMT in PH,with the aim of offering insights for inhibiting pulmonary vascular remodeling in PH.
