Progress in roles of nuclear microRNA in metabolic diseases
10.3969/j.issn.1000-4718.2025.04.021
- VernacularTitle:核内微小RNA调控代谢性疾病的研究进展
- Author:
Ziyi ZHANG
1
;
Xiaofei LÜ
1
;
Sijia LIANG
1
Author Information
1. 中山大学中山医学院药理学教研室,广东 广州 510080
- Publication Type:Journal Article
- Keywords:
nuclear microRNA;
metabolic diseases;
non-canonical regulation
- From:
Chinese Journal of Pathophysiology
2025;41(4):798-803
- CountryChina
- Language:Chinese
-
Abstract:
Increasing evidence has revealed an unexpected localization of mature microRNA(miRNA)in the nucleus,exerting additional and broader functions.These findings differ from the traditional view that miRNAs in the cyto-plasm inhibit gene expression through their canonical regulation via post-transcriptional mechanisms.Metabolic diseases involve multiple organs throughout the body and rely highly on miRNA regulation.Notably,recent studies have demon-strated the newly discovered nuclear function of miRNA in regulating metabolic dysfunction-associated pathological pro-cesses.In this review,according to the classification of metabolic diseases,we summarize the current knowledge on nuclear miRNA non-canonical regulation including their working modes and potential targets,such as directly binding on gene pro-moters,noncoding RNA,or proteins,etc.,to suggest a viable strategy for the treatment of metabolic diseases.
