The role of human umbilical cord mesenchymal stem cells in skin wound repair:A literature review

VernacularTitle:人脐带间充质干细胞在皮肤创面修复中的研究进展
Author: Xinyu LIU ¹ ; Mengmeng KONG ; Yi FU ; Jialin LAI ; Jun LI ; Jianghua SUN
Author Information

1. 湖北工业大学生命科学与健康工程学院(湖北武汉 430068)
Publication Type:Journal Article
Keywords: human umbilical cord mesenchymal stem cells; skin; wound repair
From: The Journal of Practical Medicine 2025;41(21):3462-3466
CountryChina
Language:Chinese
Abstract: Mesenchymal stem cells(MSCs)are multipotent stromal cells that possess the capacity for self-renewal and differentiation into multiple cell lineages.Due to the ease of procurement,robust expansion in vitro,the multipotency,they are recognized as a vital source of stem cells in the field of regenerative medicine.MSCs can be isolated from various tissues,including bone marrow,adipose tissue,and umbilical cord.Research indicates that Human umbilical cord mesenchymal stem cells(hUCMSCs)play an effective role in wound healing and tissue regeneration,and can be utilized for the repair of skin wounds.They are also considered to be the most promising seed cells for skin tissue engineering.This review aims to provide an overview of the biological characteristics of hUCMSCs,the mechanisms in promoting skin wound healing,and their clinical applications.