Distance From the End of the Fetal Corpus Callosum to the Occipital Bone Screening for Partial Agenesis of the Corpus Callosum
10.3969/j.issn.1005-5185.2025.04.012
- VernacularTitle:胎儿胼枕径筛查部分型胼胝体发育不全
- Author:
Chunlin YIN
1
;
Juhua XIAO
;
Menglan GUO
;
Min ZHU
;
Yinhong YANG
;
Huan XIAO
;
Meizhen ZHANG
Author Information
1. 吉安市妇幼保健院功能科,江西 吉安 343000
- Publication Type:Journal Article
- Keywords:
Agenesis of corpus callosum;
Ultrasonography,prenatal;
Distance from the posterior edge of the terminal corpus callosum to the occipital bone;
Clinical value
- From:
Chinese Journal of Medical Imaging
2025;33(4):403-406,408
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To explore the clinical value of screening for partial agenesis of the corpus callosum(PACC)via measuring the distance from the end of the fetal corpus callosum to the occipital bone.Materials and Methods A Prospective study were performed from October 2017 to April 2023 in Ji’an Maternal and Child Health Care Hospital and Jiangxi Maternal and Child Health Hospital.A total of 33 PACC fetuses(abnormal group)and 396 normal fetuses(normal group)were selected as the research subjects.The distance(Z value)from the terminal posterior edge of the corpus callosum to the occipital bone was measured,Z value was calculated and compared between groups.The truncation value and related diagnostic efficiency indexes were calculated by receiver operator characteristic curve analysis,and the positive rate of Z value of abnormal group was compared with that of indirect signs.Results The distance from the terminal posterior edge of the corpus callosum to the occipital bone was positively correlated with the gestational age(r=0.913,P<0.001).The best regression equation was that the distance from the terminal posterior edge of the corpus callosum to the occipital bone was 3.879+1.115×gestational age,and the standard deviation was 1.670.The results of mean comparison showed that the Z value of the abnormal group was significantly higher than that of the normal group(t=11.223 9,P<0.001).When Z value 2.199 7 was used as the cut-off value for the diagnosis of PACC,the area under the curve was 0.9981,the Yoden index was 0.959 6,and the sensitivity,specificity,positive and negative predictive values were 96.97%,98.99%,88.89%and 99.75%,respectively.The positive rate of Z value in abnormal group was significantly higher than that of indirect signs(96.97%vs.63.64%,χ2=7.692 3,P<0.01).Conclusion The distance from the terminal posterior edge of corpus callosum to the occipital bone of PACC fetus is larger than that of normal fetus.The increase of Z value indicates that the end of corpus callosum moves forward,which can be used as one of the basis for screening PACC,and it has high clinical value when Z value 2.199 7 is used as the cut-off value for PACC screening.
