The impact of fluoride exposure through drinking water on the risk of hypertension among residents in Jishan County, Shanxi Province
10.3760/cma.j.cn231583-20241230-00436
- VernacularTitle:山西省稷山县饮水型氟暴露对居民高血压患病风险的影响
- Author:
Ying LIU
1
;
Wenbo LYU
;
Chao ZHANG
;
Yang LIU
;
Yuting JIANG
;
Lihua WANG
;
Yanmei YANG
;
Haiyan JIA
;
Peng LUO
;
Yanhui GAO
Author Information
1. 哈尔滨医科大学中国疾病预防控制中心地方病控制中心地氟病防治研究所，哈尔滨 150081
- Publication Type:Journal Article
- Keywords:
Fluorine;
Urine;
Hypertension;
Risk assessment
- From:
Chinese Journal of Endemiology
2025;44(8):603-608
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the impact of fluoride exposure through drinking water on the risk of hypertension among residents in Jishan County, Shanxi Province.Methods:From March to April 2023, a cluster sampling method was used to select permanent residents aged ≥18 years and residing for ≥10 years in 12 villages in drinking water-borne endemic fluorosis areas of Jishan County, Shanxi Province as the survey subjects. A questionnaire survey, physical examination, and morning urinary fluoride level testing were conducted. The least absolute shrinkage and selection operator (Lasso) regression were used to analyze the key influencing factors of hypertension. Restricted cubic spline was used to evaluate the linear relationship between urinary fluoride and hypertension. Logistic regression was used to analyze the impact of urinary fluoride on hypertension.Results:Finally, 2 453 survey subjects were included, aged (62 ± 10) years, including 1 565 patients (63.80%) with hypertension. There were significant differences in the distribution of age, gender, education level, annual household income, body mass index (BMI), and the level and distribution of urinary fluoride between hypertension group and normal blood pressure group ( P < 0.05). The Lasso regression results showed that age, education level, BMI, and urinary fluoride were the key influencing factors of hypertension, with coefficients of 1.04, - 0.12, 0.24 and 0.01, respectively. The results of the restricted cubic spline showed that there was a linear relationship between urinary fluoride and hypertension after adjusting for age, education level, and BMI ( Poverall = 0.018, Pnonlinear = 0.482). The logistic regression results showed that after adjusting for age, education level, and BMI, urinary fluoride > 4.68 mg/L was a risk factor for hypertension ( OR = 1.42, 95% CI: 1.10 - 1.84, P = 0.007). Conclusion:High urinary fluoride is a risk factor for hypertension in drinking water-borne endemic fluorosis areas of Jishan County, Shanxi Province.
