Relationship between preoperative blood glucose control and perioperative insulin resistance in patients with diabetes mellitus complicated by cervical cancer and its effect on prognosis
10.12007/j.issn.0258-4646.2025.04.006
- VernacularTitle:术前血糖控制与糖尿病合并宫颈癌患者围手术期胰岛素抵抗的关系及对预后的影响
- Author:
Hongbing QIU
1
;
Yanan REN
;
Xiaoming LI
;
Zhen XIE
Author Information
1. 邢台市人民医院妇科,河北邢台 054000
- Publication Type:Journal Article
- Keywords:
cervical cancer;
diabetes mellitus;
insulin resistance;
prognosis
- From:
Journal of China Medical University
2025;54(4):318-322
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between preoperative blood glucose control and perioperative insulin resistance(IR)in patients with diabetes mellitus(DM)complicated by cervical cancer(CC)and its effect on prognosis.Methods A total of 100 patients were categorized into IR(n=61)and non-IR(n=39)groups based on their IR levels.Additionally,patients were classified into poor prognosis(n=34)and good prognosis(n=66)groups according to the occurrence of adverse events during the follow-up period.The clini-cal data of each group were compared to evaluate the association of glycosylated hemoglobin(HbA1c),fasting plasma glucose(FPG),and two-hour postprandial plasma glucose(2hPG)with perioperative IR,as well as correlation between HbA1c,FPG,and 2hPG levels and the homeostasis model assessment(HOMA)of IR with the risk of poor prognosis.Results HbA1c,FPG,2hPG,and HOMA-IR were identi-fied as risk factors for the prognosis of patients with DM and CC(P＜0.05).Compared with the respective control groups,the IR group and poor prognosis group had higher preoperative levels of HbA1C,FPG,and 2hPG(P＜0.05).Conclusion Poor preoperative blood glucose control is positively correlated with the risk of perioperative IR in patients with DM and CC.Moreover,HOMA-IR,HbA1c,FPG,and 2hPG are independent risk factors for poor prognosis in patients with DM and CC.
