Predictive value of combined detection of serum vWF,MCP-1,and GDF-15 for postpartum hemorrhage in patients with pernicious placenta previa
10.12007/j.issn.0258-4646.2025.04.011
- VernacularTitle:血清vWF、MCP-1、GDF-15联合检测对凶险性前置胎盘患者产后出血的预测价值
- Author:
Huiqiang LIU
1
;
Yanping WEI
1
;
Fei MENG
1
;
Wen ZHANG
1
;
Xicui LIU
1
;
Nina DING
1
Author Information
1. 山西医科大学第二医院妇产科,太原 030000
- Publication Type:Journal Article
- Keywords:
von Willebrand factor;
monocyte chemotactic protein-1;
growth differentiation factor-15;
pernicious placenta previa;
post-partum hemorrhage;
prediction
- From:
Journal of China Medical University
2025;54(4):346-350,358
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the predictive value of the combined detection of serum von Willebrand factor(vWF),monocyte chemotactic protein-1(MCP-1),and growth differentiation factor-15(GDF-15)for postpartum hemorrhage in patients with pernicious placenta previa(PPP).Methods One hundred and twelve patients with PPP admitted to our hospital between January 2021 and January 2024 were selected as the study group.They were further divided into a postpartum hemorrhage group and a non-postpartum hemorrhage group and 112 pregnant women with normal placental position during the same period were selected as the control group.ELISA was used to detect serum vWF,MCP-1,and GDF-15 levels.Results Serum vWF,MCP-1,and GDF-15 levels were significantly higher in the study group than in the control group(P＜0.05).Serum vWF,MCP-1,and GDF-15 levels were significantly higher in the postpartum hemorrhage group than in the non-postpartum hemorrhage group(P＜0.05).Logistic regression analysis identified vWF,MCP-1,and GDF-15 levels as factors influencing postpartum hemorrhage for women with PPP(P＜0.05).The combination of serum vWF,MCP-1,and GDF-15 predicted postpartum hemorrhage in women with PPP better than either factor alone(P＜0.05).Conclusion Combined detection of serum vWF,MCP-1,and GDF-15 levels has predictive value for postpartum hemorrhage in women with PPP.
