Risk factors of thyroid nodules in patients with type 2 diabetes
10.3760/cma.j.cn231583-20250603-00211
- VernacularTitle:2型糖尿病患者发生甲状腺结节的危险因素分析
- Author:
Chong WANG
1
;
Lanxin KONG
;
Shuzhen WANG
;
Xiumin ZHANG
;
Junqi MA
;
Jing KANG
;
Qing LI
;
Lihua JIANG
;
Zheng SHEN
;
Li AI
Author Information
1. 菏泽市立医院内分泌科，菏泽 274000
- Publication Type:Journal Article
- Keywords:
Thyroid nodules;
Obesity;
Cholesterol;
Type 2 diabetes
- From:
Chinese Journal of Endemiology
2025;44(10):851-853
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the risk factors of thyroid nodules in patients with type 2 diabetes.Methods:Data of patients with type 2 diabetes with normal thyroid function admitted to the Department of Endocrinology of Heze Municipal Hospital from January to June 2024 were collected. Binary logistic regression was used to analyze the influencing factors of thyroid nodules in patients with type 2 diabetes, and the receiver operating characteristic curve (ROC curve) was used to evaluate the diagnostic efficacy of each influencing factor.Results:Among 162 patients with type 2 diabetes, 96 had thyroid nodules, accounting for 59.3%. The incidence of thyroid nodules in women was significantly higher than that in men (χ 2 = 4.56, P = 0.034). Multivariate logistic regression analysis showed that age (≥50 years old), overweight and obesity [body mass index (BMI)≥24.0 kg/m 2], high glycated hemoglobin (≥10%), and high total cholesterol ( > 6.5 mmol/L) were independent risk factors for thyroid nodules in patients with type 2 diabetes ( OR = 1.83, 1.67, 1.08, 3.65, P < 0.05), and men was an independent protective factor ( OR = 0.63, P = 0.039). The ROC curve results showed that total cholesterol and total cholesterol combined with glycated hemoglobin could distinguish patients with thyroid nodules from those without thyroid nodules, with AUC = 0.64 and 0.68, respectively, and the differences were statistically significant ( P < 0.05). Conclusions:The incidence of thyroid nodules in patients with type 2 diabetes is relatively high. Age, overweight and obesity, high glycated hemoglobin, and high total cholesterol are independent risk factors for thyroid nodules in patients with type 2 diabetes, and total cholesterol has the ability to distinguish patients with thyroid nodules.
