Research progress on the immunoregulatory role of the IL-33/ST2 axis in common parasitic infections
10.3760/cma.j.cn231583-20240926-00355
- VernacularTitle:IL-33/ST2轴在常见寄生虫感染中免疫调控作用的研究进展
- Author:
Tulading ALIYA
1
;
Tuxun TUERHONGJIANG
1
Author Information
1. 新疆医科大学第一附属医院消化血管外科中心肝脏腹腔镜外科，乌鲁木齐 830054
- Publication Type:Journal Article
- Keywords:
Parasitosis;
Immune regulation;
Interleukin-33;
Suppressor of tumorigenicity 2
- From:
Chinese Journal of Endemiology
2025;44(9):770-774
- CountryChina
- Language:Chinese
-
Abstract:
Interleukin (IL)-33, as a core alarmin of the IL-1 family, binds to its specific receptor suppressor of tumorigenicity 2 (ST2) to form the IL-33/ST2 axis, which exhibits dual immunoregulatory effects in various common parasitic infections. This article reviews the triple regulatory mechanisms of the IL-33/ST2 axis: activating the myeloid differentiation primary response protein 88/IL-1 receptor-associated kinase 4/tumor necrosis factor receptor-associated factor pathway to induce helper T cell (Th) type 2 cytokine secretion; driving macrophage M2 polarization; and regulating the balance between regulatory T cells and Th17 cells. The aim is to gain an in-depth understanding of the bidirectional immunoregulatory role of the IL-33/ST2 axis in five common parasitic infections and to provide a theoretical basis for developing specific treatment strategies.
