Effects of enriched environment on glucose metabolism in ischemic penumbra in rats with ischemic stroke
10.12007/j.issn.0258-4646.2025.04.008
- VernacularTitle:丰富环境对缺血性卒中大鼠缺血半暗带区葡萄糖代谢的影响
- Author:
Huiyan ZHU
1
;
Min CHEN
1
Author Information
1. 新疆维吾尔自治区人民医院康复医学科,乌鲁木齐 830001
- Publication Type:Journal Article
- Keywords:
enriched environment;
ischemic stroke;
glucose metabolism;
nimodipine;
ischemic penumbra
- From:
Journal of China Medical University
2025;54(4):328-332
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of an enriched environment on glucose metabolism in the ischemic penumbra of rats with ischemic stroke(IS).Methods SD rats were subjected to middle cerebral artery ischemia to establish an IS model.The rats were ran-domly grouped and housed under different conditions with scheduled drug administration for 21 consecutive days.Neurological function scores and TTC staining were used to assess animal IS symptoms,whereas HPLC and Western blotting were used to detect glucose me-tabolic indicators and related protein expression,respectively.Results Compared to the model group,rats in the enriched envi-ronment group showed significant improvement in IS symptoms,with increased levels of glucose metabolic indicators and related protein expression.Compared to the positive drug group,rats in the positive drug+enriched environment group showed further improvement in IS symptoms,and the levels of glucose metabolic indicators and related protein expression were further enhanced.Conclusion Enriched environment can significantly improve IS symptoms in rats,and its mechanism may be related to an increase in glucose metabolic levels.
