Advances in applications of platelet-derived extracellular vesicles in drug target delivery
10.3867/j.issn.1000-3002.2025.04.008
- VernacularTitle:血小板衍生的细胞外囊泡在靶向药物递送中的应用进展
- Author:
Yunhui PENG
1
;
Shikun ZHANG
;
Shouping JI
Author Information
1. 福州大学先进制造学院,福建 晋江 352200;军事医学研究院,北京 100850
- Publication Type:Journal Article
- Keywords:
patelet;
etracellular vesicles;
drug delivery
- From:
Chinese Journal of Pharmacology and Toxicology
2025;39(4):303-309
- CountryChina
- Language:Chinese
-
Abstract:
Extracellular vesicles(EVs)are subcellular components released by cells,which can carry proteins,lipids,mRNA and miRNA,and other biomolecules.They play a significant role in main-taining the intracellular environment and mediating intercellular communication.In recent years,EVs have attracted much attention in the field of drug delivery.Platelet-derived extracellular vesicles(P-EVs)not only possess the advantages of extracellular vesicles but also integrate the unique properties of platelets.P-EVs have unique application value in in vivo drug delivery.This article reviews the extrac-tion methods of P-EVs,their targeting mechanisms and drug loading methods as drug delivery carriers,as well as the research progress in the treatment of various diseases,providing new solutions and ideas for drug application and disease treatment.
