Research progress of lemborexant in the treatment of insomnia disor-der
10.12092/j.issn.1009-2501.2025.10.015
- VernacularTitle:莱博雷生在失眠治疗中的研究进展
- Author:
Lijia GUO
1
;
Zixuan DONG
1
;
Huizhen WU
1
Author Information
1. 河北医科大学研究生学院,石家庄 050017,河北;河北省人民医院药学部,河北省临床药学重点实验室,石家庄 050051,河北
- Publication Type:Journal Article
- Keywords:
lemborexant;
insomnia;
orexin recep-tor antagonist;
pharmacokinetics;
clinical study
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2025;30(10):1429-1435
- CountryChina
- Language:Chinese
-
Abstract:
Lemborexant is a new drug for the treatment of insomnia.It is a dual orexin receptor antagonist that competitively binds to two orexin receptors,OX1R and OX2R,inhibits orexin neuro-transmission,and regulates the sleep-wake rhythm.This article comprehensively reviews the discovery of the drug target,basic information,clin-ical studies,safety assessment,and limitation anal-ysis of lemborexant,aiming to provide a compre-hensive understanding of the current research sta-tus and achievements of this drug in clinical prac-tice.
