Diagnostic value of dynamic contrast-enhanced magnetic resonance imaging for axillary lymph node metastasis in breast cancer patients with low HER-2 expression
10.3969/j.issn.1005-202X.2025.04.007
- VernacularTitle:动态增强磁共振成像对HER-2低表达乳腺癌患者腋窝淋巴结转移的诊断价值
- Author:
Xue ZHU
1
;
Keke LI
;
Ying LIU
;
Wenjuan MA
;
Hongwei DONG
Author Information
1. 徐州医科大学附属医院影像科,江苏 徐州 221000
- Publication Type:Journal Article
- Keywords:
dynamic contrast-enhanced magnetic resonance imaging;
breast cancer;
low HER-2 expression;
axillary lymph node metastasis
- From:
Chinese Journal of Medical Physics
2025;42(4):466-470
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the role of dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI)in the diagnosis of axillary lymph node metastasis(ALNM)in breast cancer patients with low HER-2 expression.Methods A total of 297 breast cancer patients with low HER-2 expression treated at the Affiliated Hospital of Xuzhou Medical University were enrolled and divided into ALNM group(n=71)and non-ALNM group(n=226)according to whether there was ALNM.All patients underwent DCE-MRI,and DCE-MRI derived parameters were collected and analyzed.Logistic regression analysis was used to identify the risk factors for ALNM,and the efficacy of DCE-MRI in diagnosing ALNM was assessed using receiver operating characteristic curve.Results Significant differences were observed between two groups in lesion distribution,TNM staging,vascular invasion,and most DCE-MRI derived parameters including short-to-long axis ratio,Ve,Ktrans,Kep,ADC and SER(all P<0.05).Multivariate regression analysis revealed that the short-to-long axis ratio,Ve,Ktrans,Kep,ADC and SER were significant risk factors for ALNM in breast cancer patients.Comparative analysis demonstrated that the combination of DCE-MRI derived parameters yielded a maximum area under the curve of 0.976,with a sensitivity of 91.5%and a specificity of 92.9%.Conclusion DCE-MRI is an effective tool for determining the presence of ALNM in breast cancer patients with low HER-2 expression,providing significant diagnostic evidence for clinical practice.
