Research progress on the regulation of host innate immunity by structural and non-structural proteins of porcine deltacoronavirus
- VernacularTitle:猪delta冠状病毒结构蛋白和非结构蛋白调控宿主先天免疫的研究进展
- Author:
Fangxin GAO
1
;
Deyuan TANG
1
;
Zhiyong ZENG
1
;
Bin WANG
1
;
Min ZHOU
1
;
Wenwen HU
1
;
Yin-ming MAO
1
;
Piao ZHOU
1
;
Song HE
1
;
Li ZHANG
1
Author Information
- Publication Type:Journal Article
- Keywords: porcine delta coronavirus; virus protein; innate immunity; immunosuppression
- From: Chinese Journal of Veterinary Science 2025;45(9):2066-2074
- CountryChina
- Language:Chinese
- Abstract: Porcine deltacoronavirus(PDCoV)is the main pathogen of porcine deltacoronavirus dis-ease.After infection,pigsmanifest a series of main symptoms,such as persistent vomiting,watery diarrhea and severe dehydration.Pigs at almost all growth stages are likely to be infected with the virus,especially suckling piglets are much sensitive to the virus.Once PDCoV infects the host,it u-sually causes significant immunosuppression.In recent years,studies on the immunosuppressive mechanism of PDCoV have gradually attracted widespread attention.The results showed that mul-tiple proteins of PDCoV were involved in the regulation of host innate immunity,revealing the mechanism of these proteins in regulating host innate immunity.In this paper,the interaction mechanism between PDCoV protein and host innate immunity were rsummarized,which will pro-vide a theoretical basis for further understanding the pathogenesis of PDCoV and effective preven-tion and control of porcine delta coronavirus disease.
