Progress on immune evasion mechanisms of avian orthoreovirus
10.16303/j.cnki.1005-4545.2025.08.28
- VernacularTitle:禽正呼肠孤病毒逃逸宿主免疫反应机制的研究进展
- Author:
Boyi XU
1
;
Di LEI
1
;
Rendong FANG
1
;
Hongzhi WANG
1
Author Information
1. 西南大学动物医学院动物健康与动物性食品安全国际合作联合实验室,重庆 400715
- Publication Type:Journal Article
- Keywords:
avian orthoreovirus;
innate immunity;
immune escape;
interferon
- From:
Chinese Journal of Veterinary Science
2025;45(8):1801-1806,1816
- CountryChina
- Language:Chinese
-
Abstract:
Avian orthoreovirus(ARV)is a globally significant immunosuppressive pathogen in poultry,capable of infecting a range of avian species and inducing conditions such as viral arthritis,tenosynovitis,and growth retardation,thereby presenting substantial challenges to the health and economic productivity of poultry.Under persistent immune selection pressure,ARV has evolved various immune evasion strategies,facilitating virus proliferation and the spread of progeny viru-ses.This article reviews the advancements in understanding the mechanisms by which ARV antag-onizes the host immune response during infection,aiming to inform research into ARV pathogene-sis and the identification of novel vaccine targets.
