Research progress of lncRNA UCA1 in oral squamous cell carcinoma
10.13591/j.cnki.kqyx.2025.04.015
- VernacularTitle:lncRNA UCA1在口腔鳞状细胞癌中的研究进展
- Author:
Yue CHEN
1
;
Xueqian SUN
1
;
Minmin CHEN
1
Author Information
1. 徐州医科大学口腔医学院,江苏徐州(221004);徐州市口腔医院正畸科,江苏徐州(221002)
- Publication Type:Journal Article
- Keywords:
oral squamous cell carcinoma;
lncRNA UCA1;
carcinogenesis;
diagnosis and prognosis;
tumor treatment
- From:
STOMATOLOGY
2025;45(4):317-320
- CountryChina
- Language:Chinese
-
Abstract:
Oral squamous cell carcinoma(OSCC)is the most prevalent malignant tumor in the head and neck region,with a relatively high incidence and mortality rate.Long non-coding RNA(lncRNA)is an important class of non-coding RNA molecules that play a cru-cial role in the occurrence and progression of OSCC.Urothelial carcinoma associated 1(UCA1)is highly expressed in OSCC,where it regulates the biological behavior of tumor cells through miRNA sponge activity and activation of downstream signaling pathways.This ar-ticle reviews the mechanisms of action of UCA1 in OSCC and its research progress in areas such as tumor proliferation,invasion,me-tastasis,drug resistance,diagnosis,treatment and prognosis.This is expected to provide a theoretical foundation for the potential clini-cal applications of UCA1 in OSCC.
