Analysis of selenium levels in typical Keshan disease endemic and non-endemic areas of Yunnan Province and Inner Mongolia Autonomous Region
10.3760/cma.j.cn231583-20250507-00172
- VernacularTitle:云南省和内蒙古自治区典型克山病病区与非病区环境硒水平分析
- Author:
Xin ZHANG
1
;
Shuqiu SUN
1
;
Dandan LI
1
;
Hongqi FENG
1
;
Cuicui CHEN
1
;
Jie HOU
1
Author Information
1. 哈尔滨医科大学中国疾病预防控制中心地方病控制中心克山病防治研究所 国家卫生健康委病因流行病学重点实验室 地方病联合重点实验室（哈尔滨医科大学、贵州医科大学、西安交通大学），哈尔滨 150081
- Publication Type:Journal Article
- Keywords:
Keshan disease;
Selenium;
Hair;
Grain;
Soil
- From:
Chinese Journal of Endemiology
2025;44(8):652-656
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the selenium levels in hair, grain, and soil samples collected from residents in typical Keshan disease (KD) endemic and non-endemic areas of Yunnan Province and Inner Mongolia Autonomous Region (referred to as Inner Mongolia), and to provide basic data for evaluating the effectiveness of KD prevention and control strategies.Methods:In 2018, one county with a history of severe KD and one non-endemic county with a similar environment were selected from each of Yunnan Province and Inner Mongolia. Within each county, one natural village was selected as the survey site. Ten soil samples were collected from each village. Ten households were stratified based on their annual per capita income levels of low, medium, and high (3, 4, 3 households, respectively). Three samples of hair and three samples of grain were collected from each household, and selenium level was measured using hydride atomic fluorescence spectrometry.Results:A total of 118 hair samples, 125 grain samples, and 39 soil samples were collected. The selenium levels in the hair of residents from KD endemic areas were significantly lower than those from non-endemic areas within the same province ( P < 0.05), and there was no statistically significant difference in selenium levels in grain and soil ( P > 0.05). The selenium level in the hair of residents in Yunnan Province [0.36 (0.31, 0.41) mg/kg] was higher than that in Inner Mongolia [0.31 (0.25, 0.35) mg/kg, Z = - 3.87, P < 0.001]. The proportion of sufficient hair selenium levels (≥0.30 mg/kg) was 86.7% (52/60) in Yunnan Province and 55.2% (32/58) in Inner Mongolia, with a statistically significant difference (χ 2 = 14.26, P < 0.001). Selenium levels in grain and soil in Yunnan Province were lower than those in Inner Mongolia ( P < 0.001). The proportion of sufficient grain selenium levels (> 0.02 mg/kg) was 5.7% (4/70) in Yunnan Province and 12.7% (7/55) in Inner Mongolia, with a significant difference (χ 2 = 11.88, P = 0.003). The selenium levels in soil in both provinces reached the sufficient level (≥0.20 mg/kg). Conclusions:The selenium levels in the population of KD endemic areas are lower than those in non-endemic regions, and the selenium deficiency among residents in Inner Mongolia is more prominent than in Yunnan Province. The selenium levels in Inner Mongolia's grain and soil are higher than those in Yunnan Province. In the future prevention and control of KD attention should be paid to monitoring the selenium nutrition level of the population in KD areas, especially in Inner Mongolia areas located in the north.
