Correlative study on the expressions of JMY and WHAMM,autophagic dysfunc-tion,and prognosis in glioma
10.13315/j.cnki.cjcep.2025.09.004
- VernacularTitle:JMY、WHAMM表达与胶质瘤自噬障碍及预后的相关性
- Author:
Zhangwei FAN
1
;
Leiming WANG
1
;
Yanlei XIONG
1
;
Min GAO
1
;
Zeliang HU
1
;
Lihong ZHAO
1
;
Lianghong TENG
1
Author Information
1. 首都医科大学宣武医院病理科,北京 100053
- Publication Type:Journal Article
- Keywords:
gliomas;
JMY;
WHAMM;
autophagy
- From:
Chinese Journal of Clinical and Experimental Pathology
2025;41(9):1142-1148
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To investigate the correlation between two autophagy-related proteins,JMY and WHAMM,and autophagic dysfunction and prognosis in gliomas.Methods A total of 113 cases of diffuse gliomas and 14 control brain tissues were collected.The expression of JMY,WHAMM,and autophagy-related markers were evaluated using the EnVision two-step method of immunohistochemistry.Correlations between the expression of JMY and WHAMM and clinicopathological features,prognosis,and autophagy markers were analyzed.Results The high expression rates of JMY and WHAMM in control brain tissue were significantly higher than those in diffuse gliomas.The expressions of JMY and WHAMM were associated with pathological grade and age.Compared with low-grade gliomas(LGG),high-grade gliomas(HGG)showed significantly lower high-expression rates of JMY and WHAMM.Patients with low expres-sion of JMY and WHAMM had shorter overall survival than those with high expression.Cox regression analysis indica-ted that the high pathological grade and low expression of JMY were independent prognostic risk factors.The expression profiles of autophagy markers suggested reduced autophagic activity in HGGs,and JMY expression was positively corre-lated with autophagy markers.Conclusion The high expression rates of JMY and WHAMM are significantly lower in HGGs compared to LGGs.JMY and WHAMM may serve as potential molecular markers for the prognostic evaluation of diffuse gliomas.
