Progress of research and clinical applications of TERT promoter mutationsins in adult-type diffuse gliomas
10.13315/j.cnki.cjcep.2025.09.014
- VernacularTitle:成人型弥漫性胶质瘤TERT基因启动子突变研究及应用进展
- Author:
Zhendong JIANG
1
;
Bingkun WANG
1
;
Wenjun LUO
1
;
Cuiyun SUN
1
;
Shizhu YU
1
Author Information
1. 天津医科大学总医院/天津市神经病学研究所神经病理研究室,天津 300052
- Publication Type:Journal Article
- Keywords:
adult-type diffuse gliomas;
TERT promoter mutation;
molecular type;
prognosis;
diagnosis
- From:
Chinese Journal of Clinical and Experimental Pathology
2025;41(9):1206-1210
- CountryChina
- Language:Chinese
-
Abstract:
Telomerase reverse transcriptase(TERT)promoter mutation(TPM)in the TERT gene is one of the most frequent genetic alterations in adult-type diffuse gliomas,particularly in IDH-wildtype glioblastoma and IDH-mu-tant oligodendroglioma with 1p/19q co-deletion.Consequently,the WHO(2021)classification of tumors of the central nervous system incorporates TPM as a key molecular criterion for molecular subtyping and grading,differential diagno-sis,prognosis assessment,and treatment-planning in these gliomas.This article briefly reviews the physiological roles of TERT,the relationship between TPM and gliomagenesis.In order to provide reference for clinical practice.
