The mediating role of thyroid stimulating hormone levels in osteoporosis in patients with type 2 diabetes mellitus and menopause
10.3969/j.issn.1006-6187.2025.04.007
- VernacularTitle:2型糖尿病绝经期患者促甲状腺激素水平与骨质疏松发生风险相关性的研究
- Author:
Yanjing LIU
1
;
Xiaofen LIAN
1
;
Fan ZHANG
1
;
Yuan LIN
1
Author Information
1. 518000 北京大学深圳医院内分泌科
- Publication Type:Journal Article
- Keywords:
Osteoporosis;
Thyroid stimulating hormone;
Diabetes mellitus,type 2;
Influencing factors
- From:
Chinese Journal of Diabetes
2025;33(4):273-279
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the mediating effect of thyroid stimulating hormone(TSH)levels on the risk of osteoporosis(OP)in patients with T2DM and menopause.Methods A total of 179 menopausal T2DM patients who were admitted to our hospital from January 2020 to January 2023 were enrolled in this study.All the participants were divided into diabetes without complication group(T2DM group,n=95)and diabetes with complication group(Com group,n=84)according to the co-existence of complications.Logistic regression analysis was used to analyze the influencing factors for T2DM complications.According to the co-existence of OP,all the patients were divided into OP group(n=86)and Non-OP group(n=93).And the influencing factors for OP occurrence are analyzed using random forest algorithm.Logistic regression analysis was used to investigate the relationship between TSH and T2DM complications and OP.The Bootstrap method was used to analyze the mediating effect of TSH between T2DM complications and OP.Results DM duration,HbA1c,free triiodothyronine,free thyroxine,and TSH were independent influencing factors for T2DM complications(P＜0.05),while P1NP,TSH,vitamin D,and DM duration were influencing factors for the occurrence of OP.After adjusting for confounding factors,there was a negative correlation between TSH and the risk of T2DM complications(P＜0.05),and a negative correlation between TSH and OP(P＜0.05).Mediation effect analysis showed that TSH played a mediating role between T2DM complications and OP.Conclusions TSH is negatively correlated with the risk of T2DM complications and OP,and plays a mediating role between T2DM complications and OP,partially mediating the impact of T2DM complications on OP.
