Correlation between thyroid peroxidase antibody and renal function injury in type 2 diabetes mellitus patients with Hashimoto thyroiditis and euthyroidism
10.3969/j.issn.1006-6187.2025.04.004
- VernacularTitle:2型糖尿病合并桥本甲状腺炎患者甲状腺过氧化物酶抗体与肾功能损伤相关性的研究
- Author:
Wenlong ZHANG
1
;
Peng YE
1
Author Information
1. 610021 成都市第二人民医院内分泌与代谢性疾病科
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus,type 2;
Hashimoto thyroiditis;
Peroxidase antibody;
Urinary albumin to creatinine;
Estimate glomerular filtration rate
- From:
Chinese Journal of Diabetes
2025;33(4):259-263
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between thyroid peroxidase antibody(TPO-Ab)and renal function injury in type 2 diabetes mellitus(T2DM)patients with Hashimoto thyroiditis(HT)and euthyroidism.Methods A retrospective analysis was performed on 180 newly diagnosed T2DM patients admitted to the Department of Chengdu Second People's Hospital from January 2020 to December 2022,including 75 cases without HT(T2DM group)and 105 cases with HT and euthyroidism(HT group).The clinical features,UACR and eGFR between the two groups were compared and analyzed.Results The level of UACR in HT group was higher than that in T2DM group[22.72(17.46,43.45)vs 20.60(14.67,27.32)mg/g,P＜0.05].eGFR was lower than that of T2DM group[(87.47±14.61)vs(94.64±10.32)ml/(min·1.73 m2),P＜0.05].Correlation analysis showed that TPO-Ab was positively correlated with UACR(r=0.376,P＜0.05),and negatively correlated with eGFR(r=-0.354,P＜0.05).Multiple linear regression analysis suggested that TPO-Ab was an influential factor for UACR and eGFR.Conclusions TPO-Ab is associated with kidney injury in T2DM.HT may aggravate kidney injury in T2DM patients through TPO-Ab.
