Relationship of the Cyclin B2 and Cyclin E1 expression with clinicopathological characteristics and 5-year survival rate of patients with hepatocellular carcinoma
10.3969/j.issn.1005-6483.20240902
- VernacularTitle:细胞周期蛋白B2、细胞周期蛋白E表达与肝癌病人临床病理特征及5年生存率的关系分析
- Author:
Li FANG
1
;
Yunxiao TIAN
;
Qingli GAO
;
Guangxu NIU
Author Information
1. 056000 河北邯郸,邯郸市中心医院病理科
- Publication Type:Journal Article
- Keywords:
hepatocellular carcinoma;
Cyclin B2;
Cyclin E1;
clinicopathological features;
prognosis
- From:
Journal of Clinical Surgery
2025;33(9):981-984
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expressions of cyclin B2(CCNB2)and cyclin E1(Cyclin E1)in hepatocellular carcinoma(HCC)and their significance for the prognosis of HCC.Methods Sixty HCC patients were admitted and treated from October 2013 to October 2016.The expressions of CCNB2 and Cyclin E1 in 60 HCC tissues and adjacent normal tissues were detected by immunohistochemistry,and the relationship between the two and the clinicopathological characteristics of HCC patients was analyzed;Spearman method was performed to analyze the correlation of CCNB2 and Cyclin E1 expression;Kaplan-Meier was performed to analyze the relationship between CCNB2,Cyclin E1 expression and clinical prognosis;and univariate and multivariate Cox regression were performed to analyze the influencing factors of clinical prognosis of HCC patients.Results The positive expression rates of CCNB2 and Cyclin E1 in HCC(61.67％,56.67％)were significantly higher than those in adjacent normal tissues(20.00％,13.33％,P＜0.05);the positive expressions of CCNB2 and Cyclin E1 were positively correlated with serum AFP level,liver cirrhosis status,tumor thrombus and recurrence(P＜0.05).The expressions of CCNB2 and Cyclin E1 in HCC tissues were positively correlated(r=0.487,P=0.000).The positive expressions of CCNB2 and Cyclin E1 in HCC tissues predicted a lower survival time(x2=7.104,7.140,P=0.008,0.008).In addition,the positive expressions of CCNB2 and Cyclin E1 were independent factors affecting the prognosis of HCC patients(P＜0.05).Conclusion CCNB2 and Cyclin E1 are highly expressed in HCC and are associated with serum AFP level,cirrhosis status,tumor thrombus and recurrence,and can be used as independent prognostic markers.
