Epidemic characteristics and pathogen analysis of human brucellosis in Heze City, Shandong Province from 2009 to 2023
10.3760/cma.j.cn231583-20240403-00083
- VernacularTitle:2009—2023年山东省菏泽市人间布鲁氏菌病流行特征和病原学分析
- Author:
Zongkun FU
1
;
Wei LIU
;
Xianghui WEI
Author Information
1. 菏泽市疾病预防控制中心检验科，菏泽 274000
- Publication Type:Journal Article
- Keywords:
Brucellosis;
Epidemiological characteristics;
Pathogen analysis
- From:
Chinese Journal of Endemiology
2025;44(7):568-572
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the prevalence and pathogenic characteristics of human brucellosis in Heze City, and provide scientific basis for formulating corresponding prevention and control strategies.Methods:A retrospective study was conducted, the data of brucellosis cases in Heze City from 2009 to 2023 were collected from the China Disease Control and Prevention Information System. The pathogen monitoring data of acute phase patients at various brucellosis monitoring sites in Heze City from 2018 to 2023 were collected from the strain review report of the Shandong Provincial Center for Disease Control and Prevention. Descriptive epidemiological analysis of the three distribution patterns (time, region, population distribution) and pathogen monitoring results of human brucellosis in Heze City were conducted.Results:From 2009 to 2023, a total of 3 232 cases of brucellosis were reported in Heze City, with no deaths. The annual incidence rate ranged from 0.93/100 000 to 5.23/100 000, and the annual average incidence rate was 2.53/100 000, with the highest incidence in 2018. The difference of incidence rate of brucellosis in different years was statistically significant (χ 2 = 767.85, P < 0.001), showing an overall upward trend (χ 2trend = 15.33, P < 0.001). The 3 232 cases of brucellosis were reported from January to December, with the peak incidence mainly concentrated from March to August, accounting for 65.75% (2 125/3 232) of the total reported cases. The regional distribution was mainly concentrated in Yuncheng County, Mudan District, and Cao County, accounting for 62.78% (2 029/3 232) of the total reported cases. The incidence rate of brucellosis in Mudan District, Cao County, Shan County, Chengwu County, Juye County, Yuncheng County, Dingtao District, Dongming County, and the Economic and Technological Development Zone all showed an upward trend year by year ( P < 0.05). The population affected by brucellosis was mainly male, with a male to female ratio of 2.46∶1.00 (2 299∶933). The age of onset was mainly concentrated at 25 - < 65 years old, accounting for 79.98% (2 585/3 232). The occupational distribution was mainly dominated by farmers, accounting for 81.96% (2 649/3 232). The results of pathogen monitoring showed that a total of 66 Brucella strains were detected in the blood culture samples of 197 acute phase patients, all of which were Brucella melitensis. The main type was biovar 3, accounting for 84.85% (56/66). Conclusions:The overall human brucellosis epidemic in Heze City is on the rise, with a slight decline after 2019 but still higher than early levels. The epidemic shows obvious seasonality, with relatively concentrated regional distribution, and the affected population is mainly male farmers. The dominant type is Brucella melitensis biovar 3. We should strengthen livestock quarantine and monitoring and prevention of high-risk populations to control the development of brucellosis outbreaks.
