Correlation between neutrophil-lymphocyte ratio and diabetic kidney disease
10.3969/j.issn.1006-6187.2025.04.005
- VernacularTitle:中性粒细胞/淋巴细胞比值与糖尿病肾脏疾病相关性的研究
- Author:
Yufei YUAN
1
;
Zhongwei FANG
;
Yang WANG
Author Information
1. 252600 聊城市第二人民医院肾内科
- Publication Type:Journal Article
- Keywords:
Diabetic kidney disease;
Neutrophil-lymphocyte ratio;
Multivariate regression analysis
- From:
Chinese Journal of Diabetes
2025;33(4):264-268
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association between neutrophil-lymphocyte ratio(NLR)and diabetic kidney disease(DKD)in patients with type 2 diabetes mellitus(T2DM).Methods 548 T2DM patients hospitalized in The Second People's Hospital of Liaocheng from January 2022 to March 2023 were divided into control(Con,UACR≤30 mg/g,n=393)group,microalbuminuria(Mic,UACR 30～300 mg/g,n=103)group and macroalbuminuria(Mac,UACR＞300 mg/g,n=52)group according to the levels of UACR.Results In the Con,Mic and Mac groups,blood urea nitrogen(BUN),serum creatinine(Scr),serum uric acid(SUA),cystatin C(CysC)and total cholesterol(TC)increased successively(P＜0.05),and estimated glomerular filtration rate(eGFR)decreased successively(P＜0.05).The systolic blood pressure(SBP),NLR,neutrophil count and lymphocyte count(Lym)in the Mic and Mac groups were higher than those in the Con group(P＜0.05).The age,DM duration and hypertension duration in the Mic group were higher than those in the Con group(P＜0.05),and the hemoglobin(Hb)in the Mac group was lower than that in the Con group(P＜0.05).Logistic regression analysis showed that Hb,Lym,age,SBP,NLR,BUN,Scr,eGFR,SUA,CysC,DM duration,hypertension,hypertension duration,and the use of antihypertensive drugs were all influencing factors for the occurrence of DKD.After adjusting for multiple confounding factors,it was shown that NLR(OR 1.223,95%CI 1.082～1.382),SBP(OR 1.018,95%CI 1.005～1.031),and eGFR(OR 0.973,95%CI 0.954～0.991)remained the influencing factors of DKD.In male DKD patients across different age groups,with BMI＜29.9 kg/m2,non-smoking,non-drinking and without comorbid diabetic retinopathy and hypertension,the NLR was significantly higher compared to the Con group(P＜0.05).However,no interaction effects were observed between these variables and NLR in relation to DKD(P＞0.05).Conclusions NLR is closely related to the occurrence and development of DKD.
