Research progress on animal models of Alzheimer's disease

VernacularTitle:阿尔茨海默病的动物模型研究进展
Author: Yifan BAI ¹ ; Lu LIU ; Yilin LI ; Jinxin MIAO ; Jun WANG
Author Information

1. 河南中医药大学,中医药科学院,郑州 450046
Publication Type:Journal Article
Keywords: Alzheimer's disease; cognitive dysfunction; animal model; animal of genetic modification
From: Acta Laboratorium Animalis Scientia Sinica 2025;33(9):1381-1392
CountryChina
Language:Chinese
Abstract: Alzheimer's disease(AD)is common neurodegenerative diseases that is the main causes of cognitive dysfunction and behavioral abnormalities.Constructing animal models with similar characteristics to human patients is crucial for advancing investigations of AD,and to develop new therapeutic drugs.Combined with the latest research progress,this review classifies animal models of AD according to aging models,genetically modified models,and chemically induced models.This review systematically summarizes the commonly used animal models of AD,and elucidates the modeling mechanisms and pathological changes,and compares their advantages and limitation,with a view to provide method ological references for researchers in selecting appropriate animal model for AD investigation.